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Doctor in Matthew Perry ketamine overdose case agrees to plead guilty: DOJ

June 18, 2025
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Michael Buckner/Getty Images

One of the two doctors charged in connection with Matthew Perry‘s ketamine death case has agreed to plead guilty to distributing the drug, the Department of Justice said Monday.

Dr. Salvador Plasencia is expected to plead guilty to four counts of distribution of ketamine in the coming weeks, the DOJ said.

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The charge carries a statutory maximum sentence of 40 years in federal prison, prosecutors said.

Plasencia is one of five people charged in the wake of Perry’s death from a ketamine overdose at his home on Oct. 28, 2023, at the age of 54. The Friends actor was discovered unresponsive in a jacuzzi at his Los Angeles home, police said. An autopsy report revealed he died from the acute effects of ketamine.

Plasencia, who operated an urgent care clinic in Malibu, had been set to go on trial in August in the case.

His plea agreement comes after Mark Chavez, the other doctor charged in the case, pleaded guilty to distributing ketamine in October 2024. Chavez is scheduled to be sentenced in September.

According to Plasencia’s plea agreement, which was filed on Monday, he distributed 20 vials of ketamine, ketamine lozenges and syringes to Perry and the actor’s live-in assistant, Kenneth Iwamasa, between Sept. 30, 2023, and Oct. 12, 2023.

Plasencia “admits that his conduct fell below the proper standard of medical care and that transfers of ketamine vials to Defendant Iwamasa and Victim M.P. were not for a legitimate medical purpose,” his plea agreement stated.

Iwamasa, who admitted in court documents to administering the ketamine on the day that Perry died, pleaded guilty in August 2024 to one count of conspiracy to distribute ketamine causing death, the DOJ said. He is scheduled to be sentenced in November.

Plasencia’s attorney, Stefan Sacks, told ABC News following Plasencia’s arraignment in August 2024 that a plea deal was possible in the case.

According to his plea agreement, Perry asked Iwamasa to help him procure ketamine in September 2023 and provided his assistant with “money, or promised to reimburse him, and directed him to find sources from whom to acquire the drugs.”

One of Plasencia’s patients introduced him to Perry on Sept. 30, 2023, with the unidentified patient referring to the actor as a “‘high profile person” who was seeking ketamine and was willing to pay “cash and lots of thousands” for ketamine treatment,” according to Plasencia’s plea agreement.

Plasencia contacted Chavez, who had previously owned a ketamine clinic, to discuss Perry’s request for ketamine and purchased vials of liquid ketamine, ketamine lozenges and other items from him, according to the agreement.

Plasencia administered ketamine to Perry at the actor’s home on several occasions, as well as left vials and lozenges with Iwamasa to administer, according to the plea agreement. In one instance, he was paid $12,000 for such a visit, according to the agreement.

One instance occurred outside of the home, when Plasencia administered ketamine to Perry in a parking lot near an aquarium in Long Beach, according to the plea agreement. Upon learning about that, Chavez “reprimanded” the other doctor “for “dosing people in cars, and in a public place where children are present,” Chavez’s plea agreement stated.

Plasencia returned to Perry’s home on Oct. 12, 2023, to administer ketamine, during which the actor’s blood pressure spiked, causing him to “freeze up,” according to Plasencia’s plea agreement.

“Notwithstanding Victim M.P.’s reaction, defendant left additional vials of ketamine with Defendant Iwamasa, knowing that Defendant Iwamasa would inject the ketamine into Victim M.P.,” the agreement stated.

After receiving 10 more vials of ketamine through a licensed pharmaceutical company using his DEA license, Plasencia texted Iwamasa on Oct. 27, 2023, according to the plea agreement: “I know you mentioned taking a break. I have been stocking up [in] the meanwhile. I am not sure when you guys plan to resume but in case its when im out of town this weekend I have left supplies with a nurse of mine …I can always let her know the plan.”

Perry died the following day after overdosing on ketamine, which Plasencia had not provided, according to the plea agreement.

Another defendant in the case, Eric Fleming, admitted in court documents that he distributed the ketamine that killed Perry, prosecutors said. He pleaded guilty in August 2024 to one count of conspiracy to distribute ketamine and one count of distribution of ketamine resulting in death. He admitted in court documents that he distributed 50 vials of ketamine that he obtained from another defendant in the case — Jasveen Sangha — to Iwamasa, including the ketamine that killed Perry, the DOJ said. Fleming is scheduled to be sentenced in November.

Sangha, allegedly known as “The Ketamine Queen,” is accused of selling 50 vials of ketamine over two weeks to Perry, working with Fleming and Iwamasa to distribute the drugs to Perry, prosecutors said. She is accused of selling Perry the batch of ketamine that killed him.

Sangha pleaded not guilty and is scheduled to go on trial in August.

Copyright © 2025, ABC Audio. All rights reserved.

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